San Francisco 49ers Schedule 2022
| Game | Date | Kickoff | Opponent | Final |
| Pre | Fri, Aug. 12 | 5:30 PM |
 |
49ers vs. Green Bay |
| Pre | Sat, Aug. 20 | 4:00 PM |
 |
49ers at Vikings |
| Pre | Thurs, Aug. 25 | 5:15 PM |
 |
49ers at Texans |
| 1 | Sun, Sep. 11 | 10:00 AM |
 |
49ers at Bears |
| 2 | Sun, Sep. 18 | 1:05 PM |  |
49ers vs. Seahawks |
| 3 | Sun, Sep. 25 | 5:20 PM |
 |
49ers at Broncos |
| 4 | Mon, Oct. 3 | 5:15 PM |  |
49ers vs. Rams |
| 5 | Sun, Oct. 9 | 1:05 PM |
 |
49ers at Panthers |
| 6 | Sun, Sep. 16 | 10:00 AM |
 |
49ers at Falcons |
| 7 | Sun, Oct. 23 | 1:25 PM |
 |
49ers vs. Chiefs |
| 8 | Sun, Oct. 30 | 1:25 PM | |
49ers at Rams |
| 9 | Sun, Nov. 6 |
BYE WEEK |
||
| 10 | Sun, Nov. 13 | 5:20 PM |
 |
49ers vs. Chargers |
| 11 | Mon, Nov. 21 | 10:00 AM |
 |
49ers vs Cardinals (Mexico City) |
| 12 | Sun, Nov. 27 | 1:25 PM |
 |
49ers vs. Saints |
| 13 | Sun, Dec. 4 | 1:05 PM |  |
49ers vs. Dolphins |
| 14 | Sun, Dec. 11 | 1:25 PM |
 |
49ers vs. Buccaneers |
| 15 | Thurs. Dec. 15 | 5:15 PM |
|
49ers at Seahawks |
| 16 | Sat, Dec. 24 | 1:05 PM |
 |
49ers vs. Commanders |
| 17 | Sun, Jan. 1 | 1:05 PM |
 |
49ers at Raiders |
| 18 | Sun, Jan. 8 | TBD |
|
49ers vs. Cardinals |