San Francisco 49ers Schedule 2021
| Game | Date | Kickoff | Opponent | Final |
| Preseason | Sat, Aug. 14 | 5:30 PM |
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19 - Chiefs 16 - 49ers |
| Preseason | Sun, Aug. 22 | 4:30 PM |
 |
15 - 49ers 10 - Chargers |
| Preseason | Sun, Aug. 29 | 1:00 PM |
 |
10 - Raiders 34 - 49ers |
| 1 | Sun, Sep. 12 | 10:00 AM |
 |
41 - 49ers 33 - Lions |
| 2 | Sun, Sep. 19 | 10:00 AM |  |
17 - 49ers 11 - Eagles |
| 3 | Sun, Sep. 26 | 5:20 PM |  |
30 - Packers 28 - 49ers |
| 4 | Sun, Oct. 3 | 1:05 PM |  |
28 - Seahawks 21 - 49ers |
| 5 | Sun, Oct. 10 | 1:25 PM |  |
10 - 49ers 17 - Cardinals |
| 6 | Mon, Oct. 17 |
BYE WEEK |
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| 7 | Sun, Oct. 24 | 5:20 PM |
 |
30 - Colts 18 - 49ers |
| 8 | Sun, Oct. 31 | 10:00 AM |
| 33 - 49ers 22 - Bears |
| 9 | Sun, Nov. 7 | 1:25 PM | |
31 - Cardinals 17 - 49ers |
| 10 | Mon, Nov. 15 | 5:15 PM | 
|
10 - Rams 31 - 49ers |
| 11 | Sun, Nov. 21 | 10:00 AM |
 |
30 - 49ers 10 - Jaguars |
| 12 | Sun. Nov. 28 | 1:25 PM |
 |
34 - 49ers 26 - Vikings |
| 13 | Sun, Dec. 5 | 5:20 PM | |
30 - Seahawks 23 - 49ers |
| 14 | Sun, Dec. 12 | 10:00 AM |
 |
26 - 49ers 23 - Bengals |
| 15 | Sun, Dec. 19 | 1:05 PM |
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13 - Falcons 31 - 49ers |
| 16 | Thurs, Dec. 23 | 5:20 PM |
|
17 - 49ers 20 - Titans |
| 17 | Sun, Jan. 2 | 1:05 PM |
|
7 - Texans 23 - 49ers |
| 18 | Sun, Jan. 9 | 1:25 PM |
|
24 - Rams 27 - 49ers |
| 19 | Sun, Jan. 16 | 1:25 PM | 
|
23 - 49ers 17 - Cowboys |
| 20 | Sat, Jan. 22 | 5:15 PM |
|
13 - 49ers 10 - Packers |